Factory Supply Pharma Intermediate 2′-Deoxycytidine CAS 951-77-9

• CAS No.: 951-77-9
• Formula: C9h13n3o4
• EINECS: 213-454-1
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 951-77-9
• Colour: White
• Sample: Available
• MOQ: 1kg
• Storage: Cool Dry Place
• Self-Life: 3 Years
• Transport Package: Drum
• Specification: Powder
• Trademark: Labeyond
• Origin: China
• Production Capacity: 10mt/Month

Product Description

2'-Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. This compound slows the cell cycle by interfering with the methylation of the P15/INK4B gene, increasing the expression of P15/INK4B protein which subdues the transformation of MDS to leukemia.
Deoxycytidine can also serve as a biomarker for tumor diagnosis. Deoxycytidine can be used as a biomarker for breast cancer patients and healthy individuals. 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. 5-hmdC levels were significantly reduced in urine samples of breast cancer patients, while 5-fodC and 5-cadC levels were elevated.
2'-Deoxycytidine is a very important pharma intermediate.

Test Items	Acceptance criteria	Results
Appearance	White to off-white powder	White powder
Identification (HPLC)	The retention time of the major peak from the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.	Complies
Water Content% (K.F.)	≤1.0%	0.3%
Specific Rotation (10mg/ml, HO)	+56.0°~+61.0°	+59.1°
Related substance (HPLC)	Any individual unspecified impurity≤0.5% (275nm)	0.4%
Purity (HPLC)	≥99.0% (275nm)	99.6%
Assay (on anhydrous basis)	98.0%~102.0%	100.2%